Around 4:15pm a crash occurred on the A27 between Fishbourne Roundabout and Stockbridge Roundabout.
The indicant involved a lorry and at two cars, One of the cars had rolled over.
Two air ambulances were sent to the scene along with emergency Services from the West Sussex Fire , Sussex police and South Coast Ambulance service.
Five people have been reported to have been taken to Hospital, No one has has suffered any life threating injuries.